嚼檳榔與非酒精性脂肪肝的關係－桃園地區職場工作者族群之探討

Betel Nut and the Risk of Non-Alcoholic Fatty Liver among Workers at Taoyuan Area in Taiwan

曾嵩智(Sung-Chih Tseng) ； 蕭添木(Tien-Mu Hsiao) ； 李俊賢(Jun-Sen Lee) ； 楊豐碩(Feng-Shuo Yang) ； 謝泉發(Chuan-Fa Hsieh) ； 許詩典(Shih-Tien Hsu) ； 張煥禎(Huan-Cheng Chang) ； 周騰達(Tang-Tat Chau)

《中華職業醫學雜誌》 17卷3期 (2010/07) Pp. 171-179

https://doi.org/10.30027/CJOM.201007.0003

摘要

嚼檳榔是台灣地區口腔癌的主要危險因子，嚼檳榔也與肝硬化、肝癌、心血管疾病、代謝症候群相關。根據調查，台灣社區脂肪肝盛行率大約30~50%，但嚼檳榔是否與脂肪肝有關，目前仍不清楚，本研究以2006至2008年，桃園縣一所優等區域教學醫院接受年度健康檢查之職場男性員工（健檢項目包含腹部超音波查檢查者）為研究對象，探討非酒精性脂肪肝的危險因子，並分析嚼檳榔與罹患非酒精性脂肪肝的關係。
本研究共納入3118名男性為有效樣本。其中非酒精性脂肪肝有1565人(50.2%)，嚼檳榔有343人(11.0%)。經多變項羅吉斯迴歸分析發現：非酒精性脂肪肝盛行的危險因子有高年齡層、體重過重、肥胖、糖尿病、高膽固醇、高三酸甘油酯、肝功能(ALT)異常及高尿酸。嚼檳榔與罹患非酒精性脂肪肝並無顯著相關。在此次研究樣本中，非酒精性脂肪肝的盛行率高達50.2%。這顯示非酒精性脂肪肝是職業醫學上值得持續關注的健康問題。

關鍵字

非酒精性脂肪肝 ； 檳榔

並列摘要

Chewing betel nut is the main risk factor of oral cancer, and is related to liver cirrhosis, hepatocellular carcinoma, cardiovascular diseases, and metabolic syndrome in Taiwan. Not only high hepatitis B infection prevalence and high hepatocellular carcinoma mortality, but also 30%~50% high prevalence of non-alcoholic fatty liver were found in Taiwan. The relationship between betel nut use and non-alcoholic fatty liver remains unclear. In this study we recruit male workers who received health checkups, including abdominal echo examination and laboratory test, at Landseed hospital, Taoyuan, Taiwan, in 2006 to 2008. We investigate the risk factors of non-alcoholic fatty liver among workers in Taiwan, especially the use of betel nut.
Among 3118 male workers, 1565 (50.2%) was non-alcoholic fatty liver case, 343 (11.0%) workers chewed betel nut. After performing multiple logistic regression modeling, the risk factors associated with the non-alcoholic fatty liver were age, over-weight, obesity, diabetes, hypercholesterolemia, hyperchlesterolemia, high ALT, high uric acid. No significant association was found between non-alcoholic fatty liver and the use of betel nut.

並列關鍵字

non-alcoholic fatty liver ； betel nut