Hydrofluoric acid is widely used in industrial operations such as etching, decontamination, rust removal and cleaning. Because of the harsh characteristics, there is danger of contact burns and necrosis of adjacent tissues. The subsequent absorption and penetration into deep tissues and bloodstream or other organs cause an increasing risk of toxicity and mortality. The decontamination usage of hydrofluoric acid for tissue corrosiveness and systematic toxicity of Hydrofluoric acid had been suggested as the first line in some papers recently. So, we intended to review its feasibility from current literature.