Various hydrodynamic models are used for prediction of wave loads on a high-speed displacement vessel and integrated with a structural Finite Element model for quasi-static structural analysis These hydrodynamic models include 2D strip theory, 3D pulsating source distribution method and 3D translating pulsating source distribution technique Comparisons between numerical results and experimental data for wave loads on the vessel are made to establish uncertainties due to three-dimensional effect and forx4ard speed effect Using short-term and long-term statistical analysis, extreme wave loads obtained by these models are compared with rule based values Furthermore, wave patterns, dynamic pressure distributions, the stress strain responses of the vessel to different hydrodynamic loadings are discussed.