A 72-year-old male patient with no obvious asbestos exposure history complained of a nonproductive cough lasting for months, and presented with an unusual upper right lobe mass with a cavity and pleural invasion on the chest radiograph. Fluorescence bronchoscopy revealed a bronchogenic malignancy in the upper right lobe bronchus. An exploratory thoracotomy was performed and demonstrated an upper right lung mass with severe pleural adhesion. An upper right lobectomy and a palliative resection of the right 6th and 7th rib tumors were done. Detailed pathologic studies, including immunohistocytochemical staining, proved an extensive malignant mesothelioma with a right main bronchus invasion and lymph node metastasis. This pattern of the clinical and radiographic presentation has seldom been reported, and the fluorescence bronchoscopic finding has never been described as an indication of malignant mesothelioma.