Pulmonary mucormycosis is an uncommon opportunistic mycoses that is indistinguishable from bacterial pneumonia, and usually has a rapid progression. It is very important to obtain histopathologic specimens and a diagnosis with more invasive procedures. The risk of massive hemoptysis makes us believe that surgery is an essential part of the management of this disease. In a 70-year-old diabetic female who was developing pulmonary mucormycosis, intravenous amphotericin B therapy was initially started due to the high risk of surgery. A lobectomy, left upper lobe, was performed in spite of clinical improvement and a partial roentgenographic resolution within 2 months of medical therapy. The patient was regularly followed up at the OPD now. Combined medical-surgery therapy is an alternative for those with solitary pulmonary mucormycosis and who are poor candidates for surgery initially.