Esophageal complications induced by radiotherapy are not uncommon. Although esophageal stricture after radiotherapy still is a relatively rare complication, the incidence and severity of esophagitis has increased when radiotherapy is combined with chemotherapy. We present a patient with stage Ⅲb adenocarcinoma of the lung, who developed esophageal stricture after induction chemotherapy, followed by concurrent chemo-radiotherapy. The chemotherapeutic agents that might increase the effects of radiation are reviewed. For the management of patients who developed esophageal stricture, medical treatment with supportive care is usually used. Balloon dilatation is another choice. However, the recurrence rate is high. Surgical intervention is used when medical treatment is ineffective.