A Rare Case of Malignant Gastrointestinal Stromal Tumor of the Esophagus in a Patient with Chronic Cough

胃腸基質瘤是一種腸道基質細胞所分化出組織主質上之原始細胞瘤。主要發生的位置是胃和小腸，大腸次之發生於食道則相當少見，大部分臨床症狀都已腸冑道出血或阻塞來表現。在此報告一位六十四歲女性病人過去並無任何病史病人先以慢性咳嗽表現約半年直到病人的咳嗽加劇合併喘，心悸等病人才開使就醫。意外的而在胸部X光片發現左下葉肺之巨大腫瘤，胸部電腦斷層掃描卻發現是食道腫瘤並向外生長。初疑為食道之肌肉瘤。術後經免疫細胞生化之切片染色才証實為少見的食道冑腸基質瘤。術後臨床狀況包括咳嗽，喘等均獲得改善且追蹤胸部X光片在半年後也無復發現象。

關鍵字

食道胃腸基質瘤；免疫細胞生化切片染色

並列摘要

Gastrointestinal stromal tumors (GISTs) are a subset of gastrointestinal mesenchymal tumors of varying differentiation. GISTs are predominately found in the stomach and intestines, but have not been documented in the esophagus. Most GISTs present typically with dysphagia, gastrointestinal bleeding, or a palpable mass. Herein, we present a rare case of an esophageal GIST which presented without gastrointestinal-associated symptoms or signs, but with chronic cough. The esophageal GIST was proven by immunohistochemical stain after the operation. The dyspnea on exertion, palpitation, and chronic cough clearly improved after the tumor was enucleated. We present this rare case and review the recent literature regarding the definition, diagnosis and treatment options of GISTs.

並列關鍵字

chronic cough ； gastrointestinal stromal tumor ； c-kit ； immunohistochemical stain

國際替代計量

A Rare Case of Malignant Gastrointestinal Stromal Tumor of the Esophagus in a Patient with Chronic Cough

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