Multiple Pulmonary Tumors as the Initial Manifestation of Cervix Uteri Malignant Melanoma-A Case Report

肺部多發性腫瘤為初始表現之原發子宮頸黑色素細胞癌－一病例報告

吳政哲(Cheng-Che Wu) ； 李毓芹(Yu-Chin Lee) ； 彭瑞鵬(Reury-Perng Perng)

《胸腔醫學》 21卷1期 (2006/02) Pp. 40-45

https://doi.org/10.29806/TM.200602.0006

摘要

原發於子宮頭的黑色素細胞癌相當罕見。合併肺部轉移的子宮頸黑色素細胞癌更是少見。子宮頸黑色素細胞癌在臨床上診斷不易而且被診斷出來時已通常相當晚期，預後也不好。常見於肺部轉移的原發腫瘤有乳癌、頭頸部腫瘤、大腸癌或胃癌。黑色素細胞癌常轉移侵犯至肺部。常見的影像學表現為多發性結節或腫塊。肺部多發性腫瘤若診斷為黑色素細胞癌轉移時，應仔細檢查病患的皮膚或黏膜是否有原發黑色素細胞癌。黑色素細胞癌主要治療方式為手術切除。病人的預後好壞通常決定於病人的術前診斷分期。

關鍵字

黑色素細胞癌 ； 子宮頸 ； 肺部轉移

並列摘要

We report a case of malignant melanoma of the cervix uteri with multiple lung metastasis diagnosed in a 39-year-old female patient. The patient presented persistent cough with scanty sputum as the first symptom, and no pigmented lesion of the anus, vulva, or skin. The chest film showed multiple varied nodules and masses at both lungs. Pathology of the bronchoscopic biopsy via LB6 showed malignant melanoma. Cytology of the uterine cervix smear revealed malignant melanoma. Colposcopy showed a 0.5×0.8×0.5-cm sized, pigmented lesion on the anterior lip of the cervix. Pathology of the biopsy showed malignant melanoma. Brain computed tomography showed multiple metastasis of the brain. We review the literature and discuss the clinical manifestation, radiographic evaluation, and adjuvant therapy of metastatic melanoma.

並列關鍵字

melanoma ； cervix ； lung metastasis