Pulmonary Arterial Hypertension Related to Human Immunodeficiency Virus Infection: A Case Report and Literature Review

人類後天免疫缺陷病毒感染所導致之肺動脈高壓－病例報告及文獻回顧

陳碩爵(Shuo-Chueh Chen) ； 何茂旺(Mao-Wang Ho) ； 涂智彥(Chih-Yen Tu) ； 白培英(Pei-Ying Pai) ； 施純明(Chuen-Ming Shih)

《胸腔醫學》 21卷3期 (2006/06) Pp. 261-267

https://doi.org/10.29806/TM.200606.0006

摘要

愛滋病的肺部併發症是感染人類後天免疫缺陷病毒病人主要致死原因之一。慢性非感染性肺部併發症，如肺動脈高壓，已被充分研究且發生率約0.5%。但其病態生理學及首選治療仍不清楚。在此我們報告一位35歲男性病人，因感染人類後天免疫缺陷病毒而引起肺動脈高壓。病患持續接受高活性抗反轉錄病毒藥物及兩週的diltiazem（每天60毫克）治療但肺動脈高壓仍未好轉。我們建議若有年輕病患因肺動脈高壓產生運動性呼吸困難求診，在排除常見原因後，原發性肺高壓，包括人類後天免疫缺陷病毒感染所引起的肺動脈高壓應列入考慮。

關鍵字

肺動脈高壓 ； 人類後天免疫缺陷病毒 ； 高活性抗反轉錄病毒藥物

並列摘要

Pulmonary complications of acquired immunodeficiency syndrome (AIDS) represent major causes of mortality in human immunodeficiency virus (HIV)-infected patients. The occurrence in these patients of chronic pulmonary non-infectious complications, such as pulmonary arterial hypertension (PAH), is well established, and the incidence is about 0.5%. But the pathogenesis and treatment of choice are unclear. Herein, we report the case of a 35-year-old man who had PAH related to HIV infection. He received highly active antiretroviral therapy (HAART) and a 2- week daily diltiazem 60 mg treatment, but the pulmonary arterial pressure did not improve. We suggest that if a young patient suffers from dyspnea on exertion due to pulmonary arterial hypertension, with no other common etiology, pulmonary arterial hypertension related to HIV infection should always be kept in mind.

並列關鍵字

pulmonary arterial hypertension ； human immunodeficiency virus ； highly active antiretroviral therapy