Squamous Papilloma and Papillomatosis of the Airway-A Report of 3 Cases

呼吸道鱗狀上皮乳突瘤－病例報告

蘇剛正(Kang-Cheng Su) ； 盧崇正(Chong-Chen Lu) ； 彭瑞鵬(Reury-Perng Perng)

《胸腔醫學》 21卷4期 (2006/08) Pp. 382-391

https://doi.org/10.29806/TM.200608.0012

摘要

多发性鱗狀上皮乳突瘤症在上呼吸道是一種常見於小孩的呼吸道良性腫瘤，好患於喉部，其病原為人類乳突狀病毒家族。此病的常見特徵之一就是疣狀生長的病兆常會頻繁的復發以及往外擴散。而單一之鱗狀上皮乳突瘤則罕見，從上呼吸道至下呼吸道皆有可能發生，抽菸為主要誘發因子，好發於抽菸之成人男性，只有少數病例與人類乳突狀病毒感染相關。手術將病灶處完全切除是預防擴散及復發的重要關鍵。如果病灶一直復發，最嚴重的後遺症就是造成呼吸道阻塞及病灶轉變為惡性。我們報告三個病例，一個為發生於氣管之單一乳突瘤，兩個為喉部復發性乳突瘤症合併上呼吸道阻塞，其中一位在發病48年後發生惡性轉變。同時我們回顧文獻並提出討論。

關鍵字

鱗狀上皮乳突瘤 ； 復發性呼吸道乳頭狀瘤症 ； 人類乳頭狀病毒

並列摘要

Squamous papillomatosis of the airway is an uncommon disease. One of its common characteristic features is the frequent recurrence and extension of the warty growth of the lesions. Squamous papilloma is rare. It may occur in the upper to lower airway, and is usually seen in male adults who smoke. Complete resection of the lesions is the key to preventing their spread and recurrence. Airway obstruction and malignant transformation are the most severe complications with frequent recurrence. We report 3 cases with airway involvement. Case 1, a 45-year-old female, was diagnosed to have a solitary squamous papilloma in the trachea. She underwent complete resection of the tumor, and has enjoyed an event-free life in the 14 months following treatment, up to this writing. Case 2, a 16-year-old girl, and Case 3, a 52-year-old male, had suffered from recurrent laryngeal papillomatosis since childhood, and underwent tracheostomy to keep the airway patent, within 1 and 2 years, respectively, after the onset of the disease. Case 3 developed squamous cell carcinoma 48 years after the onset of the disease. We discuss the cases and also review the relevant literature.

並列關鍵字

squamous papillomatosis ； recurrent respiratory papillomatosis ； solitary squamous papilloma ； human papillomavirus