Pancreatic pseudocyst presenting as a mediastinal mass is very rare. Approximately 40 to 50 cases have been reported in the English literature over the last 2 decades. Usually, mediastinal tumors are asymptomatic or present with thoracic symptoms. By contrast, the most common presenting symptoms of mediastinal pancreatic pseudocysts are abdominal pain and weight loss. We report a 48-year-old man with epigastric dull pain for 4 days and weight loss of 3 kilograms in the most recent months. He had a medical history of alcoholic pancreatitis and gall bladder stone. Chest radiography showed a posterior mediastinal mass. Reformatted oblique coronary computed tomography scan of the abdomen revealed a thick-wall pseudocyst extending from the pancreas to the lower mediastinum. After mediastinotomy, the pathology of the mass was found to be compatible with the diagnosis of pseudocyst. The patient was then managed surgically by external drainage. In the follow-up visit within 1 month after discharge, no recurrent symptom was found.