Bronchopulmonary sequestration is a rare congenital or acquired malformation of the lower respiratory tract. Sequestrations are classified anatomically as intralobar sequestration, located within the normal lobe, and extralobar sequestration, located outside the normal lobe and with its own visceral pleura. Pulmonary infection, mainly bacterial, is the most common complication of bronchopulmonary sequestration. Nocardiosis is characteristically thought as an opportunistic infection in immuno-compromised patients. Sex hormones can influence cell-mediated immunity and predispose to such infection. We report the case of a middle aged woman with a concurrent history of symptomatic endometriosis under long-term treatment with medroxyprogesterone acetate, and in whom an extralobar sequestration complicated by Nocardia asteroides infection was diagnosed by video-assisted thoracoscopic surgery.