Primary Pulmonary Lymphoma-Lymphoplasmacytic Lymphoma: A Case Report and Literature Review

原發性肺惡性淋巴瘤－淋巴漿細胞惡性淋巴瘤：病例報告及文獻回顧

蔡英明(Ying-Ming Tsai) ； 黃明賢(Ming-Shyan Huang) ； 蔡忠榮(Jong-Rung Tsai) ； 蘇月秋(Yue-Chiu Su) ； 劉益昌(Yi-Chang Liu) ； 黃吉志(Jhi-Jhu Hwang)

《胸腔醫學》 23卷2期 (2008/04) Pp. 95-102

https://doi.org/10.29806/TM.200804.0004

摘要

支氣管肺癌是肺腫瘤中最常見，即使科學的進步，創新藥物的發明，支氣管肺癌仍是一個癌症相關死亡率和失能相當高的疾病。然而，除了支氣管肺癌，其他腫瘤亦不能忽略，不論是良性或惡性。胸腔內的惡性淋巴瘤，可分為原發或是續發於其他部位的腫瘤，好發於縱隔腔或是肺門。原發於肺臟惡性淋巴瘤為相當罕見的肺部惡性腫瘤，而文獻中的報導，大多為低惡性B細胞淋巴瘤。而這類的腫瘤，以目前的證據來看，是由支氣管中的黏膜相關類淋巴組織轉型而來。這一位57歲男性抽煙伴有長期咳嗽，體重下降的病人在多種診斷方法下證實為一個原發於肺部惡性淋巴瘤－淋巴漿細胞淋巴瘤，藉此提醒大家這樣一個以長期咳嗽來表現的肺部原發性惡性淋巴癌。

關鍵字

原發性肺惡性淋巴瘤 ； 淋巴漿細胞惡性淋巴瘤 ； Waldenstrom大球蛋白血症 ； 黏膜相關類淋巴組織

並列摘要

Bronchogenic carcinoma is a disease with high cancer-related morbidity and mortality despite modern diagnostic equipment and novel treatments. However, a variety of rare benign and malignant tumors other than bronchogenic carcinoma may affect the lung. Thoracic lymphomas, which are located in the mediastinum or hilum, are quite common, and can be either primary or secondary types. Primary pulmonary lymphomas (PPLs) are a rare pulmonary malignancy which has been reported sporadically. Most of the PPLs are low-grade B-cell type lymphomas, which originate from mucosa-associated lymphoid tissue (MALT) of the bronchus. We report a 57-year-old male smoker who suffered from prolonged cough- associated lung mass and weight loss, and who was later proved to have primary pulmonary lymphoma by biopsy. We present this case as a reminder to physicians of this rare disease and to review the relevant literature.

並列關鍵字

primary pulmonary lymphoma ； lymphoplasmacytic lymphoma ； Waldenstrom macroglobulinemia ； mucosa-associated lymphoid tissue MALT