- 期刊
Pulmonary Sarcomatoid Carcinoma in a Patient with Systemic Sclerosis Presenting as a Rapid-Growing Mass-A Case Report
肺類肉瘤上皮癌在一硬皮症患者：－病例報告
摘要
硬皮症的患者約有百分之十可發現腫瘤，包括肺癌，乳癌，消化道腫瘤，白血病，淋巴瘤及其他癌症。肺癌是硬皮症患者中最常見的，其次是乳癌。肺類肉瘤上皮癌是一種罕見的肺。一般認為臨床病程較為快速，而且對於傳統非小細胞肺癌所使用的化學治療反應並不顯著。目前對於肺類肉瘤上皮癌的臨床及病理表徵以及EGFR（Epidermal Growth Factor Receptor）表現盛行率仍不清楚。在此我們報告一位硬皮症患者合併肺部間質性變化，以一極快速生長之下肺葉腫塊為初始表現，經電腦斷層切片證實為肺類肉瘤上皮癌，因患者體能狀況不佳，故未接受傳統化學治療，而使用標靶（Erlotinib）藥物治療，但是治療效果不佳，患者在診斷後一個月死亡。
並列摘要
Malignancy is found in up to 10% of patients with systemic sclerosis, and has included pulmonary, breast, gastrointestinal, hematopoietic, lymphoid, and other types. Lung cancer is the most frequent type of cancer in patients with systemic sclerosis, followed by breast cancer. Pulmonary sarcomatoid carcinoma is a rare subtype of lung cancer and generally has an aggressive clinical course and limited response to systemic chemotherapy regimens for conventional non-small cell lung cancer. The clinicopathological characteristics of the disease remain unclear. We report the case of a 59-year-old woman who had systemic sclerosis for 10 years and was diagnosed with pulmonary sarcomatoid carcinoma presenting with a rapid-growing lung mass. Due to the rapidly worsening performance status, systemic chemotherapy was not administered and the patient was treated with erlotinib. The patient expired about 1 month after diagnosis.
延伸閱讀
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