Solitary pulmonary nodules are not hard to detect with a chest radiograph, but the physician needs experience to make a precise diagnosis. A solitary pulmonary nodule was incidentally found in the left upper lobe of an asymptomatic 43-year-old male who was then referred to our chest surgery department. Various tumor work-up examinations were done, but a definite diagnosis was not obtained. The final diagnosis of pulmonary infarction was gained from wedge biopsy of the tumor using video-assisted thoracic surgery. Although the incidence of pulmonary infarction is low, it should be included in the differential diagnosis of pulmonary nodules.