- 期刊
Progression of Ventilator-Induced Lung Injury in COVID-19-Related Acute Respiratory Distress Syndrome, and Therapeutic Strategies
摘要
Introduction: A common and obvious complication of progressive COVID-19 is acute hypoxemic respiratory insufficiency or failure, leading to acute respiratory distress syndrome (ARDS) and requiring oxygen therapy and mechanical ventilation. However, the pathological changes in ARDS resulting from COVID-19 are different from those of typical ARDS, and mechanically ventilated patients with COVID-19-related ARDS exhibit a higher mortality rate than do typical ARDS patients. Objective: To review published articles on this topic with the objective of determining how to minimize the progression of patient self-inflicted lung injury or ventilator-induced lung injury (VILI) and improving the survival rate of mechanically ventilated patients with COVID- 19-related ARDS. Data Source: A literature search was undertaken in the PubMed database on all related studies up to August 2020. There were no restrictions on publication date, study design or language. Study Selection: Included studies involved those that investigated the pathological changes of COVID-19-related ARDS and that proposed strategies to prevent and treat VILI in patients with COVID-19-related ARDS. Thirty-two relevant articles were selected for final review. Results: We summarized the current research on the pathophysiology of COVID-19- related ARDS and the suggested therapeutic strategies to deal with the progression of patient self-inflicted lung injury or VILI. Conclusion: According to the pathogenesis of mechanically ventilated patients with COVID-19-related ARDS, lung-protective ventilation strategies and early pharmacologic intervention may be considered not only as supportive therapy but also as preventive therapy.
延伸閱讀
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