惡性黑色素瘤治療的新境界－硼捉中子治療法

惡性黑色素瘤對傳統光子或電子射線之放射反應，有相當大的個體上差异。利用熱中子或超熱中子束撞擊同位素硼-10化合物，產生重粒子射束治療癌瘤，有輻射生物學上的優點，例如高LET射線。賦形藥(vehicle)與黑色素或前驅物結合，可選擇性攜帶硼-10至黑色素瘤細胞上，提高硼捉中子治療效果。Dr.Mishima是硼捉中子治療惡性黑色素瘤的鼻祖，1987-1993年間，臨床上共治療12位原發性或轉移性惡性黑色素瘤，成勣斐然。研發中等能量及高通量率中子射束，開發第三代含硼尋癌化合物，增加腫瘤細胞對硼-10的吸收延長硼化合物之半衰期等，以期提高治療比，是硼捉中子療法未來發展趨勢。

關鍵字

惡性黑色素瘤；硼捉中子治療

並列摘要

The radioresponsiveness of conventional photon or electron therapy for malignant melanomas has a large individual difference. Thermal or epithermal neutron impinging on the target of isotope boron-10 produces heavy particle beams. This products provide radiobiological advantage, such as high LET radiation. An vehicle binding to melanin or precussor is able to transport boron-10 onto melanoma cells significantly. This process enhances the effect of boron neutron capture therapy. Dr. Mishima, Kobe University, Japan, is a pioneer of boron neutron capture therapy on malignant melanomas. Twelve cases of primary or metastatic melanomas were treated with boron neutron capture successfully from 1987 to 1993. The development of intermediate energy with high fluence-rate neutron beam, as well as discovery of third-generation tumor-seeking boronated compounds with long half-lives in tumor cells would provide for higher therapeutic tatio. This modalities become a new trend on boron neutron capture therapy in the future.

並列關鍵字

malignant melanoma ； boron neutron capture therapy(BNCT)

國際替代計量

惡性黑色素瘤治療的新境界－硼捉中子治療法

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