病毒檢驗在腫瘤診斷與治療上的應用

病毒與腫瘤的關係非常密切，首先是在1908年，由Ellerman和Bang氏所建立。他們研究鵝的白血病時，發現白血病鵝的無細胞過濾萃取液能感染其他鵝而造成其他鵝的白血病。之後，更在其他動物如鼴鼠、貓、猿及人類身上陸續地發現可過濾的“腫瘤DNA”。本文針對病毒與腫瘤的關係、病毒與腫瘤之間關係建立的條件、與人類腫瘤有關的病毒（包括反轉錄病毒、肝炎病毒、乳突病毒、疱疹病毒）、病毒在細胞內的癌化作用以及病毒在腫瘤診斷與治療上的應用，分析已知病毒與腫瘤的研究。

關鍵字

病毒；腫瘤；癌化作用；腫瘤診斷；治療

並列摘要

The close association between tumor and virus was established in 1908 by Ellerman and Bang when they observed that chicken leukemia could be transmitted through noncellular extract from the afflicted fowl. As a result, ”tumor DNA” was successively identified in several other species, i. e., mouse, cat, monkey and human beings. In this report, we reviewed the relationship between virus and tumor, the criteria determining this relation, the virus-associated human tumors, the potential carcino-genic process of virus inside the cell, and the application of virus in the diagnosis and therapy of the tumor in human. We used Epstein-B arr virus as a model to explain the latent as well as acute infection in the carcinogenesis and the disease progression marker in human. We further extrapolated the observations from herpes-virus and retrovirus to interpret the interactions between the host genes and the viral genes in the conversion process from proto-oncogene to oncogene. Finally, we discussed the current status of application of viruses in tumor diagnosis and gene therapy. In conclusion, although virus has been closely associated with tumor, the consequential carcinogenic process between virus infection and tumor formation remains to be elucidated.

並列關鍵字

Tumor ； Viruses ； Carcinogenesis ； Diagnosis ； Treatment

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病毒檢驗在腫瘤診斷與治療上的應用

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