This paper reported a case of post-radiation nasopharyngeal carcinoma whose follow-op positive emission tomography/computed tomography (PET/CT) scan showed physiological uptake in bilateral neck soft tissue. This image pattern mimicked local recurrence. Biopsy revealed no malignant cells. One-year follow-op showed free of recurrence. PET/CT scan has been increasingly used in oncology. Physiological uptake may happen n soft tissues of neck such as muscles, fat, tonsils, lateral pharyngeal recess and salivary glands. Physiological uptake may mimic local recurrence and cause false-positive reading. Standard uptake value (SUV), image pattern and morphology change may help in differential diagnosis.