Total Marrow Irradiation with Helical Tomotherapy: A Case Report

以導航螺旋刀進行全骨髓放射線治療：病例報告

謝忱希(Chen-His Hsieh) ； 張幗孫(Ngot-Swan Chong) ； 李星怡(Hsing-Yi Lee) ； 田蕙茹(Hui-Ju Tien) ； 吳樂榮(Le-Jung Wu) ； 陳建安(Chien-An Chen) ； 林世強(Snih-Chiang Lin) ； 熊佩韋(Pei-Wei Shueng)

《放射治療與腫瘤學》 16卷2期 (2009/06) Pp. 135-142

https://doi.org/10.6316/TRO/200916(2)135

摘要

一位第三期多發性骨髓瘤之53歲亞洲女性經化學治療後決定接受自體骨髓移植治療。而自體骨髓移植治療前則接受全骨髓放射線治療。整個療程之劑量共計800cGy分成四天，每天接受200cGy之全骨髓照射劑量。接受移植後，歷經十個多月追蹤，無證據顯示其復發。全骨髓照射治療療程中，僅發生第一級之噁心及嘔吐。與過去全身放射治療經驗相較，全骨髓放射線治療較不具毒性且可達相近的治療結果。整個治療過程建議於治療前給予止吐劑以降低治療之副作用。

關鍵字

導航螺旋刀 ； 多發性骨髓瘤 ； 全骨髓放射線治療

並列摘要

A 53-year-old Asian woman with plasma cell myloma with IgG/kappa stage IIIa post chemotherapy was selected for autologous hematopoietic cell transplantation (HCT). Total marrow irradiation (TMI) tomotherapy was planned as a preconditioning regimen of HCT. A total dose of 800 cGy (200 cGy/ fraction) was delivered to the bone marrow. More than 10 months post transplant without evidence of active disease for the patient was noted. Except for Grade 1 nausea and vomiting there were no significantly adverse effects during TMI. The preconditioning regimen for the bone marrow transplant with helical tomotherapy targeting the bone marrow of the whole body is potentially less toxic and as efficacious in the patient. Antiemetics should be prescribed for the whole course of TMI for emesis prevention.

並列關鍵字

Helical tomotherapy ； Multiple Myeloma ； Total Bone Marrow Irradiation