Prognostic Factors Analysis of Lung Cancer Patients with Brain Metastasis after Whole Brain Irradiation

肺癌合併腦轉移病患經全腦放射線治療之預後因子分析

施怡婷(Yi-Ting Shih) ； 林進清(Jin-Ching Lin) ； 翁益強(Yih-Chyang Weng) ； 詹建勝(Jian-Sheng Jan)

《放射治療與腫瘤學》 18卷4期 (2011/12) Pp. 265-273

https://doi.org/10.6316/TRO/201118(4)265

摘要

Purpose: Brain metastases occur commonly in patients with lung cancer. The aim of this study is to evaluate survival outcome and prognostic factors of whole brain radiotherapy (WBRT) for lung cancer patients with brain metastases.Patients and Methods: We retrospectively reviewed the medical records of 386 lung cancer patients with brain metastases who received WBRT between January 2001 and December 2008. The end-point was overall survival (OS). Several potential prognostic factors were studied: age, gender, histology, performance status, number of brain metastases, prior therapy of lung cancer, dose schedule, and presence of extracranial metastases.Results: No patient was lost to follow-up. 374 patients died with disease and 12 patients were alive. OS ranged from 2 weeks to 40 months (median 4.7 months). In the univariate analysis, better survival was observed in age ＜ 65 years old (p＜0.0001), female gender (p＜0.0001), good performance status (p= 0.0201) and absence of extracranial metastases (p= 0.0226). In the multivariate analysis, age ＜ 65 years old (p＜0.001), female gender (p＜0.001), good performance status (p= 0.014), absence of extracranial metastases (p＜0.001) and absence of prior therapy of lung caner (p= 0.003) were favorable factors.Conclusion: The survival outcome for lung cancer patients with brain metastasis after WBRT was poor. Age ＜ 65 years old, female gender, good performance status, absence of extracranial metastases and absence of prior therapy of lung caner were favorable prognostic factors.[Therapeut Radiol Oncol 2011; 18(4): 265-273]

關鍵字

肺癌 ； 腦轉移 ； 預後因子 ； 全腦放射線治療

並列摘要

Purpose: Brain metastases occur commonly in patients with lung cancer. The aim of this study is to evaluate survival outcome and prognostic factors of whole brain radiotherapy (WBRT) for lung cancer patients with brain metastases.Patients and Methods: We retrospectively reviewed the medical records of 386 lung cancer patients with brain metastases who received WBRT between January 2001 and December 2008. The end-point was overall survival (OS). Several potential prognostic factors were studied: age, gender, histology, performance status, number of brain metastases, prior therapy of lung cancer, dose schedule, and presence of extracranial metastases.Results: No patient was lost to follow-up. 374 patients died with disease and 12 patients were alive. OS ranged from 2 weeks to 40 months (median 4.7 months). In the univariate analysis, better survival was observed in age ＜ 65 years old (p＜0.0001), female gender (p＜0.0001), good performance status (p= 0.0201) and absence of extracranial metastases (p= 0.0226). In the multivariate analysis, age ＜ 65 years old (p＜0.001), female gender (p＜0.001), good performance status (p= 0.014), absence of extracranial metastases (p＜0.001) and absence of prior therapy of lung caner (p= 0.003) were favorable factors.Conclusion: The survival outcome for lung cancer patients with brain metastasis after WBRT was poor. Age ＜ 65 years old, female gender, good performance status, absence of extracranial metastases and absence of prior therapy of lung caner were favorable prognostic factors.[Therapeut Radiol Oncol 2011; 18(4): 265-273]

並列關鍵字

Lung cancer ； Brain metastasis ； Prognostic factor ； Whole brain radiotherapy