- 期刊
- Ahead-of-Print
約氏乳酸桿菌（Lactobacillus johnsonii）GKJ2對運動表現及運動疲勞之影響
The effects of Lactobacillus johnsonii GKJ2 on exercise performance and exercise fatigue
摘要
緒論：疲勞是一種組織損傷或身體能源短缺累積的結果。研究指出，促使疲勞的因子可與腸道菌相有關。諸多研究顯示益生菌具有平衡腸道菌相、改善身體機能的效果，因此應用益生菌舒緩運動引起之疲勞是有潛力的。故本研究評估約氏乳酸桿菌（Lactobacillus johnsonii）菌株GKJ2在抗運動疲勞與提升運動表現的效益。方法：試驗設計分為實驗組與對照組，實驗組給予6週齡ICR雄性小鼠（N = 6）食用乳酸菌L. johnsonii GKJ2菌粉（200 mg/ b.w./ day）連續28天後，紀錄其運動表現以及分析運動過程中與疲勞相關的血清生化指標，評估L. johnsonii菌株GKJ2舒緩運動疲勞的效果。結果：食用28天乳酸菌L. johnsonii GKJ2菌粉後之小鼠，其游泳力竭運動時間較對照組提升約1.73倍（p < .001）。且GKJ2組之小鼠在運動過程中能維持顯著較低的血乳酸鹽濃度，並在運動後相同休息時間內維持顯著較低的血尿素氮濃度。此外，分析小鼠肝臟（p < .001）及肌肉（p < .01）組織中的肝醣含量，發現皆較對照組明顯提高。結論：綜上實驗結果，L. johnsonii GKJ2具有提升運動能力表現與降低運動後肌肉疲勞的潛能。
並列摘要
Introduction: Fatigue is a cumulative result of the tissue damage or a shortage of energy in the body. Studies have shown that one of the factors which result to the fatigue may be related to the gut microbiota. Probiotics have mostly been studied to balance the intestinal flora and improve physical function, so the application of the probiotics to ameliorate fatigue caused by exercise could be a potential solution. Therefore, this study evaluated the efficacy of Lactobacillus johnsonii strain GKJ2 in improving the exercise performance and anti-fatigue caused by exercise. Methods: An experimental group and a control group were divided in this experimental design. The 6-week-old ICR male mice (N = 6) in the experimental group was given to consume lactic acid bacteria L. johnsonii GKJ2 powder (200 mg/b.w./day) for 28 consecutive days, then the exercise performance and the serum biochemical indicators related to fatigue were analyzed to evaluate the effects of L. johnsonii strain GKJ2 on ameliorating exercise fatigue. Results: The results showed that the mice fed with L. johnsonii GKJ2 powder for 28 days had a 1.73-fold increase in the time of exhaustive swimming test when compared with the control group (p < .001). And the mice in GKJ2 group could maintain significantly lower blood lactate concentration during exercise, and maintain significantly lower blood urea nitrogen (BUN) concentration during the same rest time after the exercise. In addition, when analyzing the content of glycogen in liver (p < .001) and muscle (p < .01) tissues of the mice, it was found that both were significantly higher than those in the control group. Conclusion: To sum up the experimental results, L. johnsonii GKJ2 has the potential to improve exercise performance and reduce muscle fatigue after the exercise.