運動訓練對改善胰島素阻抗及調節脂締素機制之探討

甘乃文 ； 祁崇溥

《中華體育季刊》 25卷2期 (2011/06) Pp. 213-225

https://doi.org/10.6223/qcpe.2502.201106.2002

摘要

人體血液中的脂締素(adiponectin)與體脂肪含量、血脂異常及代謝症候群指標具有高度的相關性，尤其是中心型肥胖、胰島素阻抗(insulin resistance)、第二型糖尿病及心血管疾病患者常伴隨有低脂締素血症(hypoadiponectinemia)的現象。而有氧運動或肌力訓練，爲肥胖或第二型糖尿病患者，改善其胰島素阻抗及代謝不良指標的運動處方。數週的運動訓練計畫，對於脂締素濃度及脂締素受體(receptor)表現的提升，具有直接或間接的促進效果，可能藉由活化細胞內腺苷單磷酸活化蛋白激酶(5'-AMP-activated protein kinase, AMPK)之訊息傳遞路徑，促進肌肉細胞之粒腺體數量及氧化酵素功能，進而增加胰島素的敏感性及改善血脂狀態。因此，肥胖或胰島素阻抗族群，可藉由運動訓練活化脂締素訊息傳導路徑，提高胰島素敏感性，以降低罹患心血管及代謝疾病的風險。

關鍵字

代謝症候群指標 ； 低脂締素血症 ； 腺苷單磷酸活化蛋白激酶

參考文獻

Bays, H.,Mandarino, L.,DeFronzo, R. A.(2004).Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.Journal of Clinical Endocrinology & Metabolism.89,463-478.

Balducci, S.,Zanuso c, S.,Nicolucci, A.,Fernando, F.,Cavallo, S.,Cardelli, P.(2010).Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss.Nutrition, Metabolism & Cardiovascular Diseases.20,608-617.

Berg, A. H.,Combs, T. P.,Scherer, P. E.(2002).ACRP30 adiponectin: An adipokine regulating glucose and lipid metabolism.Trends in Endocrinology & Metabolism.13,84-89.

Blüher, M.,Bullen, J. W. Jr.,Lee, J. H.,Kralisch, S.,Fasshauer, M.(2006).Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training.The Journal of Clinical Endocrinology & Metabolism.91(6),2310-2316.

Blüher, M.,Williams, C. J.,His, A.,Ruschke, K.,Oberbach, A.,Fasshauer, M.(2007).Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.Diabetes Care.30(12),3110-3115.