In Taiwan, the highest amount of Deca-BDE was used in synthetic resin industry since 2003 to 2006 year. The aims of this study are to determine the association between serum levels of 22 PBDE congeners and health index (13 blood biochemistry and 5 hormone examinations) for workers of a representative synthetic resin plant in southern Taiwan, and then to integrate health outcomes, exposure matrix and time activity pattern to assess the occupational PBDEs exposure and health outcomes. 41 workers were grouped to three groups including manufacture (high exposure), processing (medium exposure), and officers (low exposure) by job title, PBDEs exposure possibility and time-activities data were also investigated for double-check. The average serum PBDEs levels were 1149.11, 491.59 and 102.42 ng/g lipid in high, medium and low exposure groups, respectively. The average level of PBDEs in high exposure group was significantly higher than those in other groups (p<0.0001). The dominant congeners in serum samples were BDE-209, BDE-197 and BDE-207. Moreover, the T3/T4 was significantly correlated with increasing levels of total PBDEs (p=0.0117), BDE-206(p=0.0345), BDE-207 (p=0.0034) and BDE-197 (p=0.003). We further divided all workers into two groups by serum PBDE levels, and we found the T4 levels in high serum PBDE group were significantly lower than low serum PBDE group (p=0.0220). It implied that T4 levels may be decreased by elevated PBDEs levels. In conclusion, we recommend that the manufacturing process need to improve and the workers in synthetic resin industry should enhance hazard education and equip personal protective equipments. We also suggested that PBDEs occupational exposure workers should check on T4 level regularly.
In Taiwan, the highest amount of Deca-BDE was used in synthetic resin industry since 2003 to 2006 year. The aims of this study are to determine the association between serum levels of 22 PBDE congeners and health index (13 blood biochemistry and 5 hormone examinations) for workers of a representative synthetic resin plant in southern Taiwan, and then to integrate health outcomes, exposure matrix and time activity pattern to assess the occupational PBDEs exposure and health outcomes. 41 workers were grouped to three groups including manufacture (high exposure), processing (medium exposure), and officers (low exposure) by job title, PBDEs exposure possibility and time-activities data were also investigated for double-check. The average serum PBDEs levels were 1149.11, 491.59 and 102.42 ng/g lipid in high, medium and low exposure groups, respectively. The average level of PBDEs in high exposure group was significantly higher than those in other groups (p<0.0001). The dominant congeners in serum samples were BDE-209, BDE-197 and BDE-207. Moreover, the T3/T4 was significantly correlated with increasing levels of total PBDEs (p=0.0117), BDE-206(p=0.0345), BDE-207 (p=0.0034) and BDE-197 (p=0.003). We further divided all workers into two groups by serum PBDE levels, and we found the T4 levels in high serum PBDE group were significantly lower than low serum PBDE group (p=0.0220). It implied that T4 levels may be decreased by elevated PBDEs levels. In conclusion, we recommend that the manufacturing process need to improve and the workers in synthetic resin industry should enhance hazard education and equip personal protective equipments. We also suggested that PBDEs occupational exposure workers should check on T4 level regularly.