The Application of Integra Artificial Dermis for Skin Reconstruction

自體皮膚移植是處理深層皮膚缺損的標準方法之一。然而此法存在一些缺點，例如：供皮區的傷害，可取皮的面積有限，以及植皮區疤痕孿縮等。為了避免上述情況發生，近年來一些暫時性或永久性皮膚替代品已被研發並商品化了。自1997年4月至2000年9月，我們在7個病人身上進行了10個部位的人造真皮(商品名:Integra)合併超薄分層皮膚移植或自體表皮培養細胞移植手術。手術適應症包括：肥厚性疤痕／蟹足腫；燒傷造成立即的全層皮膚缺損；以及全層皮膚病灶切除。其中一位病人在術後四個月因黑色素細胞瘤合併遠端轉移而死亡。在全部10個部位中，有兩處人造真皮發生感染。在肥厚性疤痕／蟹足腫的6個部位裡有3處再度發生不理想的疤痕。從這些病人身上得來的有限經驗裡我們知道，使用人造真皮能夠減少一些病人肥厚性疤痕或蟹足腫復發。在皮膚重建方面，人造真皮有可靠的效果，是這些病人可選擇的治療方法之一。

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並列摘要

Autologous skin grafts are used as one of the standard treatment modalities for deep skin defects. However, skin grafts exist some disadvantages such as donor site morbidities, limited donor site areas, and recipient site contractures. Hoping to eliminate all the above-mentioned problems, several skin substitutes have been developed in recent years and commercialized for temporary or permanent use^1. From April 1997 to November 2000, ten artificial dermis (Integra) followed with ultrathin split thickness skin grafts (STSG) or cultured epithelium autografts (CEA) were performed in seven patients. The indications of operation include hypertrophic scar/keloids; immediate full-thickness skin defects due to burn injury; and excision of full thickness skin lesion. One patient died of distant metastasis of melanoma four months after resurfacing surgery. Two Integra infections were identified (2/10). In the hypertrophic scar/keloids group, three of the six recipient sites developed unwanted scars again. From the limited experiences in this series, Integra artificial dermis used in hypertrophic scar/keloids might decrease the recurrence of keloid formation in some patients. For the skin resurfacing patients, Integra showed promising results and is one of the treatment alternatives for these patients.

並列關鍵字

artificial dermis ； skin graft

國際替代計量

The Application of Integra Artificial Dermis for Skin Reconstruction

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