A case of femoral neuropathy as a complication of flap excision for reconstruction of a defect due to buccal cancer excision is presented. A 51-year-old man developed numbness over his left anteromedial thigh and medial lower leg, left quadriceps weakness, and absence of left knee jerk after a flap was obtained from his anterolateral thigh. Electromyographic examination revealed evidence of denervation in the left quadriceps. A nerve conduction study showed prolonged latency, reduced amplitude of the compound muscle action potential, decreased velocity in the left femoral nerve and prolonged latency, reduced amplitude of the sensory nerve action potential, and decreased conduction velocity in the left saphenous nerve. It is suggested that this complication was caused by traction of the femoral nerve when the free antero-lateral fasciocutaneous flap was dissected. The complication may be preventable by avoiding overstretching the femoral nerve during dissection or by application of intraoperational electrodiagnostic monitoring.