Rehabilitation of Patients with MELAS Syndrome: A Case Report

MELAS症候群病人之復健：病例報告

楊佳修(Chia-Sho Yang) ； 李宗穎(Tsung-Ying Li) ； 姜蜀海(Shuu-Hai Jiang) ； 徐昌鴻(Chang-Hung Hsu) ； 許燿東(Yaw-Don Hsu) ； 張幸初(Shin-Tsu Chang)

《台灣復健醫學雜誌》 34卷3期 (2006/09) Pp. 183-188

https://doi.org/10.6315/2006.34(3)07

摘要

粒線體肌肉腦病變乳酸中毒暨類中風樣發作症候群(mitochondrial encephalomyopathy, lacticacidosis, and recurrent stroke-like episodes, MELAS syndrome)是一複雜且多系統的粒線體疾病，在臨床上並不常見。粒線體肌肉腦病變乳酸中毒暨類中風樣發作症候群病患常有肌肉無力的症狀，病患也常被要求避免運動，因而造成病患體力更加衰退。過去有關於粒線體的疾病的復健治療觀念尚未普遍接受。本文報告一位四十五歲女性，經神經科醫師診斷為粒線體肌肉腦病變乳酸中毒暨類中風樣發作症候群，該病患在病情穩定後，開始接受復健治療，本個案經低強度的復健有氧運動訓練後，有正面的效果及極佳的功能恢復。經二十個月之長期追蹤，病患仍維持在一定的肌力而功能也未變差。短期耐力訓練對該病患是有幫助的，長期追蹤及適當的運動是未來努力的重點。

關鍵字

有氧運動 ； 粒線體肌肉腦病變乳酸中毒暨類中風樣發作症候 ； 粒線體肌肉病變 ； 復健

並列摘要

MELAS (mitochondrial encephalomyopathy, lactic acidosis, and recurrent stroke-like episodes) syndrome is a mitochondrial disorder. Patients with mitochondrial myopathies typically have exercise-induced symptoms. Thus, patients are often advised to avoid exercise, which leads to deconditioning. Currently, the concept of aerobic exercise training as therapy for mitochondrial disease is not well established. We report the case of a patient with adult-onset MELAS, who responded positively to a low intensity rehabilitation program. Low intensity training was safe and significantly improved our patient's physical fitness. During the 20-month follow-up period, there was no significant reduction in muscle strength and function. Therefore, short-term endurance training was very useful in our patient. Given this result, studies with a proper aerobic exercise protocol and long-term follow-up are warranted.

並列關鍵字

aerobic exercise ； MELAS syndrome ； mitochondrial myopathy ； rehabilitation