Although mirror-image artifacts of soft tissue sonography are not common, they produce phantom pictures and may lead to misdiagnosis. Relevant literature on mirror-image artifacts, even case reports, are rare. We described a 70-year-old female initially having a painless, immovable nodule with an insidious onset on her right anterior middle leg. After she received an initial physical examination and a radiographic approach, musculoskeletal sonography disclosed an oval non-compressible hypoechoic tumor, which seemed to invade the bony cortex medial to her tibia crest. A real, dome-shaped tumor above the tibia bone with an intraosseous mirror-image artifact was detected after MRI study, and the bony cortex appeared to be quite intact. After she was transferred to the orthopedic division, undifferentiated pleomorphic sarcoma was diagnosed using tissue biopsy and a complete excision of the tumor was performed smoothly. Thus far, 30 fractions of radiotherapy and 5 courses of chemotherapy have been completed. This case report reacquaints clinicians with this vivid, misleading mirror-image artifact, which deserves further study and discussion.