Due to the increased number of aging population, the responsibility of clinical nursing care is increasing. In addition, the U.S. and European countries can no longer afford registered nurses of full amount because of medical settlement. The skill mix nursing model of combination of nurse aides and registered nurses is available and becomes popular recently. This model controls medical cost, improves patient care quality, and develops core professionalism in nursing practice. We reviewed relevant documents and provided suggestions on implementation of such a model by domestic medical institutions. We encourage more nursing specialists and scholars exploring the possibility of developing a local model which can create a win-win strategy for multiple parties in the current difficult medical environment.