合併抗生素治療對於危急病人之應用探討

Combination Antibiotic Therapy in Critically lll Patients

林梅芳(Mei-Fang Lin)

《臺灣臨床藥學雜誌》 24卷1期 (2016/03) Pp. 17-22

https://doi.org/10.6168/FJCP.2016.2401.03

摘要

多重抗藥性(multidrug resistant, MDR)細菌的產生是全球性重大難題！MDR難以治療且具高致死率，經常需要使用超過一種抗生素進行治療。但是臨床證據並不支持在大多數情況下皆使用合併抗生素治療，但是也有研究顯示合併治療有其益處。臨床若能明確判斷並定義何種情況下適合使用合併治療，並限制此特定適應症下使用，則可以有效控制抗生素過度使用。

關鍵字

多重抗藥性 ； 合併抗生素治療

並列摘要

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of global dimension. MDR infections are difficult to treat and frequently associated with high mortality. More than one antibiotic is commonly used to treat such infections, but scientific evidence does not favor use of combination therapy in most cases. However, there are certain subgroups where combination therapy may be beneficial. Identifying the subgroup of patients who are likely to benefit from combination therapy and restricting its use only for those specific indications can be helpful in controlling excessive use of antibiotics.

並列關鍵字

Multidrug Resistant ； MDR ； Combination Therapy