氫離子幫浦抑制劑造成急性廣泛發疹性膿疱症案例報告

Acute Generalized Exanthematous Pustulosis Induced by Proton Pump Inhibitors-A Case Report

林麗梅(Li-Mei Lin) ； 陳立偉(Li-Wei Chen) ； 陳怡樺(Yi-Hua Chen)

《臺灣臨床藥學雜誌》 27卷3期 (2019/07) Pp. 254-260

https://doi.org/10.6168/FJCP.201907_27(3).0010

摘要

急性廣泛發疹性膿疱症為少見的嚴重皮膚不良反應，其特性為全身紅斑處有很多無菌、非濾泡性的膿疱，但為自限性，很少會侵犯其他器官，預後良好。主要是藥品導致，以抗生素占多數。氫離子幫浦抑制劑自1989年上市後，普遍被認為是安全有效的胃酸抑制藥物，但隨著氫離子幫浦抑制劑的廣泛使用，陸續有相關的藥物不良反應發生，包括嚴重的過敏反應。本案例為1位女性疑似因使用氫離子幫浦抑制劑導致急性廣泛發疹性膿疱症。希望藉由此案例分享，讓醫療照護人員能夠及時發現罕見的藥物不良反應和妥善的處理。

關鍵字

急性廣泛發疹性膿疱症 ； 嚴重皮膚不良反應 ； 氫離子幫浦抑制劑

並列摘要

Acute generalized exanthematous pustulosis is an uncommon and severe cutaneous adverse drug reaction. Its main characteristic is the generalized formation of numerous, non-follicular, sterile pustules on an erythematous base. It is self-limited since there is an absence of systemic symptoms and extracutaneous organ involvement. Acute generalized exanthematous pustulosis is primarily associated with drugs, especially antibiotics. Proton pump inhibitors were approved in 1989. Today, they are widely used to treat acid-related disorders and are considered low-risk drugs. However, there is growing evidence of adverse reactions following the use of proton pump inhibitors, including severe hypersensitivity reactions. We present a case report about a woman who developed acute generalized exanthematous pustulosis due to proton pump inhibitor use. By reporting this case, we aim to remind clinicians to be aware of rare adverse reactions related to proton pump inhibitors.

並列關鍵字

Acute Generalized Exanthematous Pustulosis ； Severe Cutaneous Adverse Drug Reaction ； Proton Pump Inhibitor