Serum Level of Squamous Cell Carcinoma Antigen as a Marker of Disease Activity in Patients with Psoriasis

以血清鱗狀細胞癌抗原為乾癬病患疾病活性指標

石佳琦(Chia-Chi Shih) ； 陳國熏(Gwo-Shing Chen) ； 許晴哲(Roger Chin-Che Hsu) ； 李志宏(Chih-Hung Lee) ； 鍾相彬(Shiang-Bin Jong)

《中華皮膚科醫學雜誌》 20卷1期 (2002/03) Pp. 1-6

https://doi.org/10.29784/DS.200203.0001

摘要

鱗狀細胞癌抗原是子宮頸鱗狀細胞癌的腫瘤指標。近來發現良性皮膚疾病患者血清的鱗狀細胞癌抗原會升高。在這個研究，我們測定47名乾癬病患血清的鱗狀細胞癌抗原濃度，觀察此抗原是否為乾癬疾病活動力的有用標記。結果顯示有膿皰，紅皮症，及控制不良的乾癬病患，其血清的鱗狀細胞癌抗原會較高。鱗狀細胞癌抗原與身體表面受侵犯的百分比及乾癬區域嚴重度指標呈現正相關性。由此可知血清的鱗狀細胞癌抗原可能為乾癬疾病活動力的指標。此外，並就鱗狀細胞癌抗原在鱗狀細胞所扮演的生物角色加以討論。

並列摘要

Squamous cell carcinoma antigen (SCC Ag) is a tumor marker for SCC of the uterine cervix. Recently, serum levels of SCC Ag were noticed to be elevated in patients with benign dermatoses. In this study, we investigated SCC Ag levels in 47 patients with psoriasis to determine whether this Ag is a useful marker of disease activity. Our results demonstrated that patients with pustules, erythroderma and poor control status showed higher serum levels of SCC Ag. A positive correlation of SCC Ag with the percentage of body surface and psoriasis area and severity index (PASI) score was found. These data suggest that SCC Ag levels may be an indicator of psoriasis activity. Furthermore, the biological roles of SCC Ag in the squamous cells are discussed.

並列關鍵字

Squamous cell carcinoma antigen ； Psoriasis.