以MAST分析異位性皮膚炎過敏原特異型IgE抗體

Evaluation of Allergen-Specific IgE Antibodies by MAST in Atopic Dermatitis

黃玉如(Yuh-Ru Huang) ； 許漢銘(Hamm-Ming Sheu)

《中華皮膚科醫學雜誌》 22卷1期 (2004/03) Pp. 1-14

摘要

背景：血清中IgE值的增加及對食物或吸入性過敏原的特異型IgE抗體的產生為異位性皮膚炎的重要免疫異常。已知食物及各式吸入性過敏原會導致異位性皮膚炎的惡化。目的：分析南台灣異位性皮膚炎病人的吸入性，黴菌，植物及食物等過敏原的盛行率。方法：我們收集在國立成功大學附設醫院治療的異位性皮膚炎患者的血清，共507例。在此研究中，以Multiple-antigen simultaneous test (MAST)分析血清中35種過敏原特異型IgE的濃度。而血清中IgE總值則以N Latex IgE mono assay測量。結果：結果發現有60.2%病人對蟎過敏，44.2%對家塵過敏，34.7%對蟑螂過敏，21.3%對牛奶過敏。IgE總量以2歲以下病人最低，在青少年最高，嬰孩開始對食物過敏原產生過敏，而蛋白與牛奶為最常見的過敏原。孩童以後，蟎及家塵成為最常見的過敏原，而對黴菌過敏原過敏者在青少年達到高峰。對植物過敏原的過敏則隨年齡增加。結論：在南台灣，以蟎及其他吸入性過敏原為最重要的過敏原。各年齡層患者的過敏原之盛行率與西方國家類似。

並列摘要

Background: Increased serum total IgE and specific IgE antibody to ingested or inhaled antigens are one of the main immunological abnormalities in atopic dermatitis (AD), Dietary factors and a variety of inhalants have been implicated in exacerbation of AD. Purpose: The purpose of the present work is to elucidate the prevalence of inhalant, food, fungal and plant allergens in patients with AD in southern Taiwan. Methods: We collected serum sample, from 507 patients with AD who were treated at National Cheng Kung University Hospital. In this study, 35 allergen-specific immunoglobulin (IgE) antibodies were evaluated by Multiple-antigen simultaneous test (MAST). Total IgE antibodies in serum samples form subjects were measured by the N Latex IgE mono assay. Results: The results reveal the positive rates of the allergens detected by the MAST system are 60.2 % for Dermatophagoides farinae, 59% for Dermatophagoides pteronyssinus, 44.2% for house dust, 34.7% for cockroach, and 21.3 % for milk. The IgE antibody level is low in infantile group and high in adolescent/young adult group. The younger children start with allergy to food allergens. Egg white and milk are the most common sensitizers. Allergy to inhalant and fungal allergens is rare in the first two years, and gradually increases at adolescent/ young adult age. Allergy to plant allergens increases with age. Conclusion: The results indicate that mite and foods are the major sensitizing allergens in Taiwan. The prevalence of allergens in various age groups of AD in Taiwan is similar to those in western countries.

並列關鍵字

Atopic dermatitis ； IgE ； Multiple-antigen simultaneous test ； Mite ； Food allergens