第一型介白質基因多形性與牙周炎之關係

Association of interleukin-1 Gene Polymorphism with Periodontitis

張瀞文(Ching-Wen Chang) ； 賴玉玲(Yu-Lin Lai) ； 洪善鈴(Shan-Ling Hung) ； 凌莉珍(Li-Jane Ling)

《中華民國牙周病醫學會雜誌》 10卷1期 (2005/03) Pp. 61-68

摘要

牙周炎主要是由細菌所引起，患者的宿主免疫反應(host immune response)也會影響牙周炎的表現，許多學者研究第一型介白質β(interleukin-1 β)與牙周炎的關係，在牙周炎的致病機轉中，第一型介白質β是與牙周破壞有關的物質之一。近年來學者積極探討基因因素在牙周炎所扮演的角色，其中發現控制第一型介白質β生成的基因表現呈現多形性(gene polymorphism)的現象，本篇文章將介紹此第一型介白質β基因多形性，並且探討在不同人種之情形，基因多形性對第一型介白質分泌量的影響，及與牙周炎嚴重度、牙周治療的關係。

關鍵字

第一型介白質 ； 基因多形性 ； 牙周炎

並列摘要

Periodontitis is primarily caused by bacteria. However, the host immune response may influence the inflammation severity of disease. Many studies on the relationship between interleukin-1 β and periodontitis conclude that interleukin-1 is one of pro-inflammatory cytokines contributing to periodontal destruction. Researchers have recently investigated the role of genetic factor in the periodontitis, and found that interleukin-1 gene exists in polymorphous type.. This article introduces interleukin-1 gene polymorphism, its variety among different races, and the impact of interleukin-1 gene polymorphism on the amount of interleukin-1 secretion, as well as the relevance of the severity of periodontitis to the outcome of periodontal treatment.

並列關鍵字

Interleukin-1 ； gene polymorphism ； periodontitis