- 期刊
幾丁聚醣在牙周組織工程的應用
The Application of Chitosan for Periodontal Tissue Engineering
摘要
細菌性牙菌斑引起的牙周病是一為世人所重視的重要疾病。牙周病治療的終極目標是希望可以將已破壞的附連結構再生。目前臨床有很多技術發展運用於牙周組織的再生，包括：骨移植手術、引導組織再生手術及置入生長因子等，但各個技術都有其限制性。 幾丁聚醣是幾丁質的衍生物，是存在自然界很豐富的聚合物。它具有生物相容性且無毒性，容易製作成各種方便臨床操作的型式。本文藉文獻回顧詳細探討幾丁聚醣作為牙周組織工程材料的優勢。在體外實驗，幾丁聚醣可以當成很好的組織再生支架、有助於牙周細胞生長、並且可以當成攜帶生長因子的載體。在動物骨缺損模型上，幾丁聚醣可以幫助得到更多的牙周附連。除此以外，幾丁聚醣還可以幫助傷口癒合、止血、抗菌、抗發炎，並且可以幫助藥物的攜帶及釋放。 實驗證實，幾丁聚醣作為牙周再生材料，不但可以獲得較多的牙周附連結構，而且對牙周病治療的感染控制也有助益。所以幾丁聚醣可能是適合牙周組織再生工程的新材料。
並列摘要
Dental bacterial plaque induced periodontitis is one of the most important health concerns in the worldwide. The ultimate goal of periodontal therapy for destructive periodontal disease is the regeneration of the attachment apparatus. Therefore, periodontal regeneration procedures including the use of bone graft, guided tissue regeneration and a growth factor, have become more common. A significant regenerated potential of bio-material was also demonstrated in vitro and in vivo studies. Chitosan, a derivative of chitin and an abundant natural biopolymer, is biodegradable, non-toxic and formulated in a variety of forms for clinical uses. This literature was summarized the application of chitosan for periodontal tissue engineering. In vitro, chitosan can be a suitable regeneration scaffold, promote periodontal cell growth and improve intracellular signal molecular transduction. In vivo, chitosan group showed more gains of attachment apparatus in animal model. In addition, chitosan can improve wound healing, hemostasis, anti-viral, anti-inflammatory effects and be used as a drug delivery carrier. Many evidences showed this new biomaterial (chitosan) has significant results of periodontal attachment gain and periodontal inflammatory inhibition. With regard of these review, we suggested chitosan could be a potential material for periodontal regeneration.