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熱休克蛋白在牙周組織中表現之探討

Expression of Heat Shock Proteins in Periodontal Tissue

摘要


熱休克蛋白在細胞處於惡劣環境中時負責修補受損異常的蛋白質,平時並維持細胞生理機能。除了凋亡路徑中的抗凋亡作用之外,在發炎路徑中,熱休克蛋白也是重要的調控因子。在發炎性疾病像是心血管疾病、牙周炎中都發現熱休克蛋白的不同表現,可能是調控一連串發炎反應的關鍵。本文將針對熱休克蛋白之功能在牙周組織中的表現,對牙周疾病和一些發炎性疾病的影響之文獻,作一回顧整理和探討。

關鍵字

牙周病 熱休克蛋白 發炎

並列摘要


Heat shock proteins (HSPs) play a key role in correct folding of nascent and stress-accumulated misfolded proteins during stress and inflammation. HSPs not only allow the cells to survive in otherwise lethal conditions, but also play an essential role in intracellular ”house-keeping” by assisting cell physiological function. In addition to regulatory function in apoptotic pathway, HSPs also act as key inflammatory mediators in inflammatory pathways. Different HSPs expression levels are found in inflammatory disease such as cardiovascular disease and periodontitis, suggesting that HSPs may be key mediators of inflammatory sequence of these diseases. This article will review articles that discussed about the functions, expressions, influences, of HSPs in periodontal tissues.

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