維生素D受體基因多型性與牙周病之關連

The Relationship between Periodontitis and Vitamin D Receptor Gene polymorphism-A Review

陳涵鈺(Han-Yu Chen) ； 呂炫堃(Hsein-Kun Lu)

《臺灣牙周病醫學會雜誌》 15卷3期 (2010/09) Pp. 215-230

https://doi.org/10.6121/TAP.201009_15(3).0004

摘要

牙周病爲宿主免疫機制與細菌交互作用，進而破壞牙周組織的感染性疾病。而維生素D受體之基因多型性，與骨密度有關連，並影響到骨質疏鬆症、感染性疾病的發生，故維生素D受體基因適宜做爲牙周病易感性基因的研究對象。研究證實維生素D受體基因多型性變化與牙周病確實有顯著關連，但不同研究之結果卻時有差異。本文藉回顧過去文獻中，學者對於維生素D受體基因與牙周病易感性之相關研究，論述維生素D受體的生理功能，統整其基因多型性與牙周病之關聯，最後討論維生素D受體基因多型性如何對牙周病的易感性產生作用，並指出未來研究發展可能的方向。

關鍵字

維生素D受體 ； 牙周病 ； 基因多型性

並列摘要

Periodontal disease is an infectious disease caused by the interaction of host immune and the bacteria and thus undermines the periodontal tissue. Since vitamin D plays a role in bone homeostasis and immune response, the receptor gene may associate with the susceptibility to periodontal disease. Previous experiments confirmed that the vitamin D receptor gene polymorphism and periodontal disease was significantly correlated, but there are still contradictory results in different studies.
This article reviews the research of vitamin D receptor gene and susceptibility to periodontal disease, and to discuss the physiological function, its genetic polymorphism, and the effect of vitamin D receptor gene polymorphism to periodontal disease susceptibility.

並列關鍵字

vitamin D receptor ； periodontal disease ； gene polymorphism