The maxillary anterior region, also known as the aesthetic zone, is where the teeth and their supporting structures are readily visible. Therefore, it is a tragedy if any tooth in this area has to be extracted due to severe periodontal breakdown. Rather than the use of tooth extraction, we should treat the periodontal problems and save the teeth using regeneration techniques to maintain the health of the periodontal tissues and allow ease of cleaning. In this case, the periodontal tissues around the upper lateral incisor had undergone severe destruction on the distal side, with buccal gingival recession and insufficient keratinized gingiva. We treated these defects using an enamel matrix derivative mixed with a bone graft and combined them with a connective tissue graft. This was in order to achieve periodontal regeneration and to increase the width of the keratinized gingiva tissue. Our results showed an increase in keratinized gingiva tissue, a decrease in the clinical attachment level, a decrease in the probing depth, and the reduced presence of bony defects at 1 year post-treatment.