The University of Hong Kong Medical School adopted a new curriculum in 1997, taking a problem-based learning and integrative approach that includes both basic sciences and clinical aspects. The impact of the new curriculum on the teaching and learning of physiology has been twofold. Firstly, only those lectures and practicals in physiology that were considered relevant to the PBL cases were retained. Secondly, clinical aspects, namely diagnosis and treatment of disease, are now included in the teaching and learning during the first two years. There is concern that, at the end of the second year, students from the new curriculum may not be as knowledgeable in physiology as students in the old curriculum were. On the other hand, they are more knowledgeable in the clinical aspects and may under-stand better the relevance of the basic principles in physiology to the diagnosis and treatment of a disease. While there are complaints that the standard in physiology may be declining, it is also felt that the teaching of physiology in the old curriculum was in excess of the needs of general practitioners. It is important that any deficits are identified and remedial action implemented in the subsequent years. So we suggest that the basic science knowledge of graduates be evaluated and, if called for, physiological teaching in the final three years of the programme be strengthened.