Monoamine Oxidase a Polymorphism, Gender, and Smoking as Predictors for Treatment Respose in Olanzapine-treated patients with Schizophrenia

MAOA基因型、性別及抽菸為精神分裂症病人在Olanzapine治療反應之預測因子

鍾廷聖(Ting-Sheng Chung) ； 龍佛衛(For-Wey Lung) ； 曾冬勝(Dong-Sheng Tzeng)

《台灣精神醫學》 24卷4期 (2010/12) Pp. 291-300

https://doi.org/10.29478/TJP.201012.0005

並列摘要

Objective: The aim of this study was to explore the treatment effect of olanzapine on the polymorphisms of monoamine oxidase A (MAOA) in schizophrenia. Method: During a 3-month period, 60 patients with schizophrenia were administered olanzapine. Treatment response was assessed by checking for improvement in symptoms as measured on the Positive and Negative Syndrome Scale (PANSS). Results: The short form of MAOA demonstrated a better drug response in the dimension of aggression. Female patients had a better response to olanzapine. Patients who did not smoke had a better response to olanzapine in the dimension of aggression. Conclusion: The results of this study suggest that polymorphisms of MAOA, gender, and cigarette smoking may be three useful response predictors in schizophrenic patients who were treated with olanzapine.

並列關鍵字

MAOA polymorphism ； treatment response ； olanzapine ； schizophrenia

參考文獻

Murphy, D.L.,Wyatt, R.J.(1972).Reduced monoamine oxidase activity in blood platelets from schizophrenic pa-tients.Nature.238,225-226.

Wyatt, R.J.,Potkin, S.G.,Murphy, D.L.(1979).Platelet monoamine oxidase activity in schizophrenia: a review of the data.Am J Psychiatry.136,377-385.

DeLisi, L.E.,Neckers, L.M.,Staub, R.A.,Zalcman, S.J.,Wyatt, R.J.(1980).Lymphocyte monoamine oxidase activity and chronic schizophrenia.Psychiatry Res.2,179-186.

Owen, F.,Bourne, R.C.,Crow, T.J.,Fadhli, A.A.,Johnstone, E.C.(1981).Platelet monoamine oxidase activity in acute schizophrenia: relationship to symptomatology and neuroleptic medication.Br J Psychiatry.139,16-22.

Meltzer, H.Y.,Duncavage, M.B.,Jackman, H.,Arora, R.C.,Tricou, B.J.,Young, M.(1982).Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients.Am J Psychiatry.139,1242-1248.