Probable Early-onset Alzheimer's Disease Diagnosed by Comprehensive Evaluation and Neuroimage Studies

藉由完整評估與神經影像學檢查診斷的中年早發病的阿茲海默氏症

陳鑫儀(Sin-Yi Chen) ； 楊淵韓(Yuan-Han Yang) ； 歐陽文貞(Wen-Chen Ouyang)

《台灣精神醫學》 25卷1期 (2011/04) Pp. 45-49

https://doi.org/10.29478/TJP.201104.0008

並列摘要

Objective: We present a case of a female patient who was diagnosed with early-onset dementia after we did a comprehensive evaluation. Case Report: This 50-year-old female patient who showed insidious memory impairment, disturbances in executive functioning, and significant impairment in occupational functioning. Under the assumption of early-onset Alzheimer’s dementia (AD) (＜65 years of age), we completed a detailed clinical history and physical examination as well as neuropsychological tests. The patient also received neuropsychiatric evaluation, brain magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT). Conclusion: Early-onset AD was strongly suggested basing on the findings of the clinical history, neuropsychiatric evaluation, physical examination, as well as brain MRI and brain SPECT studies. Therefore, early-onset dementia, especially in patients younger than 50 years, is rare. Accurate diagnosis of dementia subtypes is challenging. In addition to comprehensive examination, neuroimaging study can provide additional information for differential diagnosis.

並列關鍵字

Early-onset dementia ； Alzheimer's disease ； single photon emission computed tomography ； neuroimaging

參考文獻

Harvey, RJ,Rossor, MN,Skelton-Robinson, M.(1998).Young-onset Dementia: Epidemiology, Clinical Symptoms, Family Burden, Support and Outcome.London:Dementia Research Group.

Sampson,E L,Warren, J D,Rossor, M N(2004).Young onset dementia.Postgrad Med J.80,125-39.

Ratnavalli, E,Brayne, C,Dawson, K(2002).The prevalence of frontotemporal dementia.Neurology.58,1615-21.

Harvey, RJ,Skelton-Robinson, M,Rossor, MN(2003).The prevalence and causes of dementia in people under the age of 65 years.J Neurol Neurosurg Psychiatry.74,1206-9.

American Academy of Neurology(1994).Practice parameter for diagnosis and evaluation of dementia (summary statement): report of the Quality Standards Subcommittee of the American Academy of Neurology.Neurology.44,2203-6.