The Association of Mood Disorders, Psychoactive Drugs and Gastroesophageal Reflux Disease (GERD): A National Population-based Study

情感性精神疾病、精神作用藥物使用與罹患胃食道逆流之關聯性分析

潘英傑(Ying-Chang Pan) ； 楊斯年(Szu-Nian Yang) ； 諶立中(Lih-Jong Shen) ； 翁郡珮(Chun-Pei Weng) ； 張家豪(Chia-Hao Chang) ； 陶屏(Ping Tao) ； 錢慶文(Ching-Wen Chien)

《台灣精神醫學》 25卷3期 (2011/09) Pp. 180-190

https://doi.org/10.29478/TJP.201109.0007

並列摘要

Objective: This study was to examine the association of mood disorders and psychoactive drugs with GERD. Method: In this study, we retrospectively analyzed 2003-2006 Taiwan National Health Insurance Research Database (NHIRD). The case cohort included patients who were first diagnosed with a mood disorder in 2004 but did not have a previous diagnosis of GERD, and the control cohort included patients who did not have mental disorders. Both cohorts were followed over a period of two years. Mood disorders were classified as major depressive disorder or bipolar disorder, and psychoactive drugs were classified as antidepressant drugs or antipsychotic drugs. We also calculated the average daily frequency (ADF) of psychoactive drugs use before the occurrence of GERD in patients. Logistic regression was used in this study to investigate the association of mood disorders and ADF of psychoactive drugs use with GERD. Results: The incidence of GERD was 4.14% in the case cohort and 1.60% in the control cohort. The risk of GERD in patients with bipolar disorder and major depressive disorder compared with control were 1.94 and 2.48 (p＜0.001). The risk of GERD in the patients who took antipsychotic drugs or antidepressant drugs with an ADF of one or more times compared with an ADF of less than one were 1.77 and 2.55 (p＜0.001). Conclusion: Mood disorders and use of psychoactive drugs were highly associated with GERD. In addition, a patient's ADF of antidepressant use should be carefully observed, regardless of whether the patient has a mental disorder. When ADF of a patient is one or more, then the patient should be followed up for any esophageal irritability.

並列關鍵字

gastroesophageal reflux disease GERD ； mood disorders ； antipsychotic drugs ； antidepressant drugs

參考文獻

Lin, SR,Xu, GM,Hu, PJ(2007).Chinese consensus on gastroesophageal refl ux disease (GERD): October 2006, Sanya, Hainan Province, China.J Dig Dis.8,162-169.

Chow, WH,Finkle, WD,McLaughlin, JK,Frankl, H,Ziel, HK,Fraumeni, JF Jr(1995).The relation of gastroesophageal refl ux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia.JAMA.274,474-477.

Lagergren, J,Bergström, R,Lindgren, A,Nyrén, O(1999).Symptomatic gastroesophageal refl ux as a risk factor for esophageal adenocarcinoma.N Engl J Med.340,825-831.

Revicki, DA,Wood, M,Maton, PN,Sorensen, S(1998).The impact of gastroesophageal refl ux disease on healthrelated quality of life.Am J Med.104,252-258.

Ronkainen, J,Aro, P,Storskrubb, T(2006).Gastro-oesophageal refl ux symptoms and health-related quality of life in the adult general population-the Kalixanda study.Aliment Pharmacol Ther.23,1725-1733.