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Sex Difference in Dementia

失智症與兩性異同的關係

並列摘要


The overview is intended to do an introductory review on the research data related to the sex difference in dementia. The author reviews the topics of sex difference in brain function, and brain structure. Then he discusses the reason why female shows higher incidence of Alzheimer's disease in the context of general population, prevalence and incidence of dementia, neurosteroids as well as brainreserve hypothesis. Basically, all research data have shown that female elderly carries higher risk of about 1.4 times in developing dementia compared to the male counterparts. With this overview, the author hopes that the contents of this overview can stimulate Taiwanese readers and researchers to pay more attention to the topic of sex differences in dementia, especially in Alzhiemer's disease, and to do further research on this topic.

參考文獻


Jazin, E.,Cahill, L.(2010).Sex differences in molecular neuroscience: from fruit flies to humans.Nat Rev Neurosci.11,9-17.
Pease, A.,Pease, B.(2001).Why Men Don't Listen and women Can't Read Maps.New York:Crown Publishing Group.
Wilson, E. O.(1992).Sociobiology.Boston:Harvard University Press.
Schlaepfer, T. E.,Harris, G. J.,Tien, A. Y.,Peng, L.,Lee, S.,Pearlson G. D.(1995).Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study.Psychiatry Res.61,129-35.
Witelson, S. F.,Glezer, I. I.,Kigar, D. L.(1995).Women have greater density of neurons in posterior temporal cortex.J Neurosci.15,3418-28.

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