Trazodone Is Not as Effective as OtherAntidepressants in Treating a Patient withMajor Depressive Disorder

Trazodone在治療重度憂鬱症病人的療效是不如其他抗鬱劑

吳佳慶(Kah Kheng Goh) ； 譚永健(Weng-Kin Tam) ； 沈武典(Winston W. Shen)

《台灣精神醫學》 26卷4期 (2012/12) Pp. 311-315

https://doi.org/10.29478/TJP.201212.0009

並列摘要

Background: Trazodone in clinical use is ineffective because of its sedation to let patient receive an adequate dose for treating a patient with major depressive disorder. We are report a case report to demonstrate this clinical efficacy issue in the treatment with trazodone. Case Report: A 83-year old male Taiwanese patient had suffered from MDD for six months. He did not response to the treatment of trazodone 150 mg/day for four months, but consequently, he responded to the treatment of milnacipran 100 mg/day or mirtazapine 30 mg/day. Conclusion: Psychiatrists in Taiwan should be alert to the fact that trazodone is not as effective as other antidepressants, and that trazodone should not be prescribed as a single antidepressant in treating an MDD patient.

並列關鍵字

antidepressant therapy ； suicide ； venlafaxine ； bupropion

參考文獻

American Psychiatric Association(2010).Practice Guideline for the Treatment of Patients with Major Depressive Disorder.Arlington, Virginia, USA:American Psychiatric Association.

Wu-Chou, A. I.,Shen, W. W.(2012).Complex behaviors related to zolpidem: an analysis of published clinical case from Taiwan.Journal of Experimental and Clinical Medicine.4,113-8.

Wu, C. S.,Shau, W. Y.,Chan, H. Y.,Lee, Y. C.,Lai, Y. J.,Lai, M. S.(2012).Utilization of antidepressant in Taiwan: a nationwide population-based survey from 2000-2009.Pharmacoepidemiol Drug Safety.21,980-8.

Chong, M. Y.(2012).Prescribing for elderly depression: excessive or inadequate?.Asia-Pacific Psychiatry.4(Suppl I),50-1.

Cunningham, L. A.,Borison, R. L.,Carman, J. S.(1994).A comparison of venlafaxine, trazodone, and placebo in major depression.J Clin Psychopharmacol.14,99-106.