Fasting Serum Glucose Level in Unmedicated Patients with Major Depressive Disorder

發病中重鬱症病人的血糖

張維紘(Wei-Hung Chang) ； 陳瑋挺(Wei-Ting Chen) ； 張惠華(Hui-Hua Chang) ； 陳高欽(Kao-Chin Chen) ； 李怡慧(I-Hui Lee) ； 葉宗烈(Tzung-Lieh Yeh) ； 陳柏熹(Po-See Chen) ； 李嵐婷(Lan-Ting Lee) ； 楊延光(Yen-Kuang Yang)

《台灣精神醫學》 27卷2期 (2013/06) Pp. 140-147+IV

摘要

Objectives: The study was aimed to explore whether unmedicated patients with major depressive disorder (MDD) have poorer metabolic profiles than healthy normal subjects. Methods: Fifty-five unmedicated MDD patients, 25 unmedicated euthymic patients with a history of MDD, and 76 healthy subjects were matched for age, sex, body mass index, and life stress, using recent life change questionnaire. We examined the subjects' fasting glucose and other metabolic profiles. Results: The results showed significant differences among MDD patients, euthymic patients and the control group in fasting serum glucose level (p ＜ 0.05). Further analyzed data showed that the fasting serum glucose in MDD patients was significantly higher than that in the healthy controls (p ＜ 0.05), and that no significant difference in fasting serum glucose was found between euthymic patients and the others two study groups. Conclusion: This result might suggest that fasting serum glucose level would be significantly different when the degrees of MDD severity are different.

關鍵字

重鬱症 ； 代謝症候群 ； 血糖 ； 發病中 ； 憂鬱症病人

並列摘要

Objectives: The study was aimed to explore whether unmedicated patients with major depressive disorder (MDD) have poorer metabolic profiles than healthy normal subjects. Methods: Fifty-five unmedicated MDD patients, 25 unmedicated euthymic patients with a history of MDD, and 76 healthy subjects were matched for age, sex, body mass index, and life stress, using recent life change questionnaire. We examined the subjects' fasting glucose and other metabolic profiles. Results: The results showed significant differences among MDD patients, euthymic patients and the control group in fasting serum glucose level (p ＜ 0.05). Further analyzed data showed that the fasting serum glucose in MDD patients was significantly higher than that in the healthy controls (p ＜ 0.05), and that no significant difference in fasting serum glucose was found between euthymic patients and the others two study groups. Conclusion: This result might suggest that fasting serum glucose level would be significantly different when the degrees of MDD severity are different.

並列關鍵字

major depressive disorder ； metabolic syndrome ； glucose ； unmedicated ； depressed patients

參考文獻

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Carnethon, M.R.,Kinder, L.S.,Fair, J.M.,Stafford, R.S.,Fortmann, S.P.(2003).Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971-1992.Am J Epidemiol.158,416-23.

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