Association between Metabolic Syndrome and Cognitive Function in Old Adults in a Taiwanese Population

代謝症候群與台灣老年人認知功能的相關研究

林詩鈞(Eugene Lin) ； 楊智傑(Albert C. Yang) ； 蔡世仁(Shih-Jen Tsai)

《台灣精神醫學》 31卷3期 (2017/09) Pp. 232-240+iv

摘要

Objective: Previous data suggest that the metabolic syndrome (MetS) is a predictor of cognition function, but the results have been conflicting. In this study, we intended to assess whether the MetS and its individual components are associated with cognitive function in old adults (≥ 60 years old) in a Taiwanese population. Methods: We analyzed 634 Taiwanese subjects, who were all scored using Mini-Mental State Examination (MMSE). Metabolic traits such as waist circumference, serum triglyceride, serum high-density lipoprotein cholesterol, systolic and diastolic blood pressure, and serum fasting glucose were measured. Results: Our data revealed that the MetS was significantly associated with lower MMSE scores, adjusting for age, gender, and education (adjusted β = - 0.061, standard error (SE) = 0.036, p ＜ 0.01). This association was also significant after adjusting for alcohol consumption, smoking, social support, and physical activity (adjusted β = - 0.101, SE = 0.039, p ＜ 0.01). Furthermore, one of the individual components of the MetS, high blood pressure, was significantly related to lower cognition after adjustment for potential confounders (p ＜ 0.01). Conclusion: Our study indicates that the MetS was associated with lower cognitive function in elderly Taiwanese subjects.

關鍵字

aging ； cognition ； metabolic syndrome ； Mini-Mental State Examination

並列摘要

背景：過去的研究認為代謝症候群 (metabolic syndrome, MetS) 可能是認知功能變化的相關指標，但是研究的結果並不一致。在本研究中我們評估代謝症候群及其個別要素是否與台灣老年人（≥ 60 歲）的認知功能相關。方法：我們共分析了634 名台灣老年人。所有受試者進行簡短智能測驗 (Mini-Mental State Examination, MMSE) 評分。並測量代謝症狀，例如腰圍、三酸甘油脂、高密度脂蛋白膽固醇、收縮和舒張壓並空腹血糖。結果：結果顯示，在調整年齡、性別和教育後，代謝症候群與較低的簡短智能測驗分數有的顯著的相關 (adjustedβ = -0.061, standard error (SE) = 0.036, p ＜ 0.001)。在調整飲酒、抽煙、社會支持和身體活動後，這種關聯也是顯著的 (adjusted β = -0.101, SE = 0.039, p = 0.012)。此外具有代謝症候群的病人的簡短智能測驗分數在調整年齡、性別和教育後更可能在低得分層（18-23 分）(adjustedodds ratios = 1.89; 95% CI = 1.17 - 3.07; p ＜ 0.001)。這種顯著的關聯在調整飲酒、抽煙、社會支持和身體活動後持續存在 (adjusted β = -0.101, SE = 0.039, p ＜ 0.001)。此外代謝症候群的高血壓要素與調整潛在干擾因素後與較低的認知相關。結論：我們的研究證實代謝症候群與台灣老年人的認知功能變差有關。

並列關鍵字

老年人 ； 認知功能 ； 代謝症候群 ； 簡短智能測驗

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