This study aims to explore the effects of EFL learners' reading comprehension by integrating balanced reading instruction (BRI) activities in English electronic picture book (e-PB) reading. The 128 study subjects were equally divided into the BRI group and the Non-BRI group. Students in the experimental group read e-PBs with the proposed BRI activities, while those in the control group read e-PBs through the traditional instructional method. In this study, quantitative data were collected from pre-tests, post-tests, and delayed-recall tests of reading comprehension. The study found that using the BRI to read e-PBs could enhance EFL learners' reading comprehension, especially to their phonemic analysis, vocabulary acquisition, and reading ability. Consequently, the findings of this study offer pedagogical implications for applying the BRI to English reading instruction.