Antibody to Hepatitis C Virus in Multitransfused Patients with β-Thalassemia Major

重度乙型海洋性貧血患者多次輸血對C型肝炎病毒抗體影響之研究

彭慶添(Ching-Tien Peng) ； 蔡長海(Chang-Hai Tsai) ； 蔡輔仁(Fuu-Jen Tsai)

《Mid-Taiwan Journal of Medicine》 3卷2期 (1998/06) Pp. 67-71

https://doi.org/10.6558/MTJM.1998.3(2).1

摘要

本研究是以在一中台灣醫院接受輸血治療之重度乙型海洋性貧血患者56名，檢測其C型肝炎病毒抗體之表徵，發現52%患者帶有C型肝炎病毒抗體。在例行C型肝炎病毒抗體篩檢之前就已接受輸血治療的患者身上，有更高的比例帶有C型肝炎病毒抗體。一項1991年研究指出，台灣的捐血者比歐洲國家有更高的血清疾病流行率。而在C型肝炎病毒抗體陽性及陰性患者之間，其血漿氨基轉移酵素及血鐵質濃度差異並不顯著。17例肝穿刺報告中有4例病理組織為CPH，7例為CAH，而其餘6例為血色沉著病。

關鍵字

重度乙型海洋性貧血 ； C型肝炎病毒

並列摘要

This study examined the presence of anti-HCV antibodies in a group of 56 β-thalassemia major patients who received blood transfusions in a hospital in central Taiwan. Overall, 52% were found to be anti-HCV positive. A higher incidence of anti-HCV antibodies was found in patients who, during transfusion therapy, started receiving blood prior to routine screening for anti-HCV. A study indicated a higher seroprevalence among blood donors in Taiwan than in European countries in 1991. Differences in serum transaminase and ferritin concentrations between anti-HCV positive and negative patients were not significant. Results from 17 biopsies showed 4 histological diagnoses were consistent with CPH, 7 with CAH and 6 biopsies with hemochromatosis only.

並列關鍵字

β-thalassemia major ； hepatitis C virus (HCV)