人工合成腐植酸對血液凝固因子蛋白質C的影響

The Inhibition of Plasma Protein C Activity Induced by Synthetic Humic Acid

楊新玲(Hsin-LingYang) ； 周湘台(Hsiang-Tai Chou) ； 呂鋒洲(Fung-Jou Lu)

《Mid-Taiwan Journal of Medicine》 3卷3期 (1998/09) Pp. 160-165

https://doi.org/10.6558/MTJM.1998.3(3).7

摘要

本研究目的是探討人工合成腐植酸（synthetic humic acid polymer, SHA）及坤（As_2O_3）對血液凝固因子蛋白質C（protein C）活性的影響。我們發現四種單一酚酸（protocatechuic acid、venillic acid、catechol、ferulic acid）合成之多酚酸聚合物即人工合成腐植酸，可抑制活化型蛋白質C的活性和減少為活化型蛋白質C的活性速率，但三價砷則會促進。人工合成的腐植酸蜇合三價砷具協同作用，會更強烈抑制蛋白質C的活性，走向促進血液凝固。

關鍵字

人工合成腐植酸 ； 多酚酸聚合物 ； 蛋白質C ； 三價砷

並列摘要

In this study we examined the effect of synthetic humic acid (SHA) and arsenic oxide (As_2O_3) on human protein C activity. We found that four SHAs polymerized from monomeric protocatechuic acid, venillic acid, catechol and ferulic acid have the ability to dose-dependently inhibit both activated protein C activity and the activation of protein C. Arsenic oxide dose-dependently enhanced activated protein C activity. However, SHAarsenic organometallic complex is more effective in the inhibition of activated protein C activity. Protein C induced by SHA causes a thrombophilic or hypercoagulablestate, which may be one of the possible mechanisms of blackfoot disease.

並列關鍵字

synthetic humic acid ； polyphenolic polymers ； protein C ； As_2O_3