Hepatic Effects in Hyperlipidemic Patients

背景為了暸解非酒精性脂肪肝興高脂血症之間的相關性。方法於西元2000年1月至12月曾經到中國醫藥學院附設醫院作定期健康檢查的民眾為樣本，有糠尿病病史與酒癮的民眾不列入本次研究的對象，總共有186位民眾納入本次研究中。非酒精性脂肪肝是以超音波診斷，研究變項包恬：血清總膽固醇值、三酸甘油脂、低密度脂蛋白膽固醇值與高密度脂蛋白膽固醇值，統計方法採用t檢定，卡方檢定與多變項羅吉斯迴歸分析。結果其中男性佔60.8%，女性佔39.2%，年齡為44.5±12.5歲。非酒精性脂肪肝的盛行率為32.8%。在單變項分析中，男性、高膽固醇血症和高三酸甘油脂血症是非酒精性脂肪肝的相關因子。在控制其他變項之後，以多變項羅吉斯迴歸分析來看，非酒精性脂肪肝因子為男性和高三酸甘油脂血症。結論未來需要更大型的研究來探討非酒精性脂肪肝是否尚有其他的相關因子。

關鍵字

非酒精性脂肪肝；高脂血症

並列摘要

Background. This study was conducted to demonstrate the relationship between nonalcoholic fatty liver and hyperlipidemia. Methods. We retrospectively analyzed patients receiving periodic health checkups at China Medical College Hospital from January to December, 2000. Subjects with a medical history of diabetes mellitus or alcohol abuse were excluded. Totally, 186 patients (men: 60.8%; women: 39.2%) were included in this study. The mean age was 44.5 years old with a standard deviation of 12.5 years (age range,18-78). Fatty liver was diagnosed by sonography. The primary factors studied were total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol. The t test, Chi-square and multivariate logistic regression were used for statistical analysis. Results. The proportion of the subjects having nonalcoholic fatty liver was 32.8%. According to univariate analysis, male gender, hypercholesterolemia and hypertriglyceridemia were related to nonalcoholic fatty liver. After controlling for other covariates, multivariate logistic regression analysis showed that the significant factors related to nonalcoholic fatty liver were male gender (odds ratio = 4.0, 95%confidence interval = 1.8-8.8,p＜ 0.001) and hypertriglyceridemia (odds ratio =5.8,95% confidence interval = 1.8 -19.0,p＜ 0.01) Conclusions. A large detailed investigation is needed in the future to reveal the other related factors of nonalcoholic fatty liver.

並列關鍵字

hyperlipidemia ； nonalcoholic fatty liver

國際替代計量

Hepatic Effects in Hyperlipidemic Patients

全文下載

主題瀏覽